A Comprehensive Guide to Eczema Injections: What to Know Before You Start
For people battling chronic eczema, the endless cycle of flare-ups, itching, and frustration can take a serious toll. While creams and ointments work for many, others need something stronger—something that works from the inside out. That’s where eczema injections come in.
These treatments are transforming how moderate to severe atopic dermatitis is managed, offering long-term relief for people who’ve exhausted topical options. Here's what you need to know about how they work, when to consider them, and which options are currently available.
What Are Eczema Injections?
Eczema injections—also known as biologic therapies or systemic treatments—are medications that target specific immune pathways responsible for eczema inflammation. Instead of applying treatment to the skin’s surface, these medications are delivered via subcutaneous injection and work throughout the body to regulate the overactive immune responses that trigger eczema symptoms.
They're typically used when topical treatments and phototherapy are no longer effective or when flare-ups become widespread and unmanageable. These injections don’t just suppress symptoms—they help address the root causes of inflammation, itching, and scaling.
How They Work: Inside-Out Relief
Most eczema injections target proteins in the immune system, such as interleukins (IL-4, IL-13, IL-31), which contribute to chronic inflammation in eczema. By blocking these inflammatory signals, the body experiences fewer immune overreactions—leading to reduced redness, itchiness, and flare frequency.
Unlike steroids, which only treat symptoms topically, biologics are designed for long-term control and may be used continuously for months or years under medical supervision.
Leading Eczema Injections Available Today
Several FDA-approved and emerging injectable therapies have shown strong results for atopic dermatitis:
- Dupixent (dupilumab): Approved for both adults and children as young as 6 months, Dupixent blocks IL-4 and IL-13, two key drivers of eczema inflammation. It’s administered every 2–4 weeks and is often the first injectable recommended for moderate to severe eczema.
- Adbry (tralokinumab): Approved for adults, Adbry focuses specifically on IL-13, offering a more targeted alternative with fewer side effects for some patients. It’s given every two weeks following a loading dose.
- Lebrikizumab: Still under review in some countries, this promising IL-13 blocker may soon expand biologic options. Clinical trials have shown strong efficacy with minimal adverse reactions.
These drugs are administered either at a clinic or via self-injection at home, depending on the treatment plan and insurance coverage.
When Should You Consider Injections for Eczema?
Eczema injections aren’t for everyone—but they’re life-changing for the right candidate. You may want to explore biologics if:
- You have moderate to severe eczema that doesn’t respond to creams, steroids, or antihistamines.
- Your eczema affects large areas of your body or is interfering with daily life, sleep, or mental health.
- You want a long-term maintenance solution that reduces flare-ups and improves skin condition over time.
They’re often covered by insurance with prior authorization and are considered safer for long-term use than systemic steroids.
Are There Any Side Effects?
While biologics are generally well-tolerated, some people experience mild side effects such as injection site reactions, eye dryness, or cold-like symptoms. Rare but serious risks—like allergic reactions or immune suppression—should be discussed with your doctor before starting treatment.
The good news? Unlike traditional immunosuppressants, these drugs don’t broadly weaken your immune system. They target specific pathways, which lowers the risk of generalized immune suppression.
How to Get Started With Injectable Eczema Treatments
To begin, you’ll need to consult with a dermatologist or allergy specialist. Most providers will first document the severity of your eczema, review previous treatments, and assess your insurance benefits.
In many cases, manufacturers offer co-pay cards, patient assistance programs, or reimbursement support to reduce the out-of-pocket cost.
Popular starting points for patient info include the National Eczema Association and your dermatologist’s office.
Final Thoughts
Injectable treatments for eczema are ushering in a new era of symptom control and skin healing. With options like Dupixent, Adbry, and soon Lebrikizumab, people suffering from long-term, treatment-resistant eczema finally have solutions that work beneath the surface.
While they’re not an instant fix, these medications offer sustainable, life-changing relief when creams and ointments fall short. If your eczema is affecting your quality of life, it may be time to talk to your doctor about taking the next step toward injectable care.
Sources
Dupixent – https://www.dupixent.com
Adbry – https://www.adbry.com
Lebrikizumab – https://www.atsciences.com/lebrikizumab
National Eczema Association – https://nationaleczema.org
American Academy of Dermatology – https://www.aad.org