7 Best Supplements That May Help Reverse Signs of Aging

Aging is inevitable—but how we age can be influenced by lifestyle, diet, and the nutrients we give our bodies. If you’re looking to maintain your skin, energy, memory, and overall vitality, certain anti-aging supplements have been shown to support cellular repair, collagen production, and cognitive function.

Here are 7 of the most promising supplements that people use to support healthy aging—along with the key benefits each one offers.

1. Collagen Peptides

Benefit: Improves skin elasticity, reduces wrinkles, strengthens hair and nails

As we age, our natural collagen production decreases, leading to thinner skin, joint pain, and brittle nails. Collagen supplements—particularly hydrolyzed peptides—can replenish lost protein, enhance skin hydration, and support joint health. Most users take it in powder form mixed into coffee, smoothies, or water.

2. Nicotinamide Mononucleotide (NMN)

Benefit: Boosts energy, supports DNA repair, enhances cellular health

NMN is a precursor to NAD+, a molecule that fuels mitochondrial energy in our cells. NAD+ levels naturally decline with age, but supplementing with NMN may increase energy levels, improve cognitive performance, and slow age-related cellular decline. It’s one of the most researched “longevity supplements” available today.

3. Resveratrol

Benefit: Protects cells from oxidative stress, supports heart and brain health

Found in red wine and grapes, resveratrol is a potent antioxidant that helps combat free radicals and reduce inflammation—two key drivers of aging. It's also linked to improved blood flow and cardiovascular function. For maximum effectiveness, it’s often paired with NMN or quercetin.

4. CoQ10 (Coenzyme Q10)

Benefit: Increases energy, improves heart health, supports skin function

CoQ10 is essential for producing energy in cells and declines as we age, particularly after 40. Supplementing with CoQ10 can help support the heart, muscles, and brain, and it's also known to protect skin from aging caused by UV exposure.

5. Omega-3 Fatty Acids (Fish Oil or Algae Oil)

Benefit: Supports brain function, reduces inflammation, improves skin hydration

Omega-3s have well-documented benefits for brain health, joint mobility, and heart protection. They also help keep skin supple by supporting the lipid barrier. EPA and DHA—the active compounds—can also enhance mood and cognitive clarity in older adults.

6. Vitamin D3 + K2

Benefit: Strengthens bones, supports immune function, improves skin tone

Vitamin D deficiency becomes more common with age and is linked to fatigue, mood swings, poor bone health, and immune decline. When paired with K2, it also directs calcium into bones instead of arteries, supporting both bone density and cardiovascular health.

7. Curcumin (Turmeric Extract)

Benefit: Reduces inflammation, protects joints, supports brain and gut health

Curcumin is the active ingredient in turmeric and one of nature’s most potent anti-inflammatories. It helps reduce oxidative stress, which contributes to aging, cognitive decline, and joint stiffness. Look for supplements that include black pepper extract (piperine) to increase absorption.

Tips for Choosing the Right Anti-Aging Supplements

When selecting supplements, choose third-party-tested brands with clinical backing. Look for bioavailable forms (such as liposomal, chelated, or fermented versions) to ensure better absorption. Always consult a healthcare provider before starting a new supplement—especially if you’re taking medications or managing chronic conditions.

Aging well isn’t just about appearance—it’s about maintaining energy, resilience, and clarity. These supplements can support that journey when paired with good nutrition, sleep, hydration, and stress management.

Final Thoughts

Reversing aging may not mean turning back time, but it can mean slowing down cellular damage, improving function, and feeling more vibrant as the years pass. Whether you’re focused on your skin, memory, or energy, these supplements can support your body’s ability to repair, protect, and thrive.

Start with one or two based on your personal health goals, and build a routine that works naturally with your lifestyle.

Sources

Healthline – https://www.healthline.com

NIH Office of Dietary Supplements – https://ods.od.nih.gov

Harvard Health – https://www.health.harvard.edu

Cleveland Clinic – https://my.clevelandclinic.org

Examine.com – https://examine.com